CONFIRMED SPEAKERS

While previous research has suggested a prospective therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), anecdotal reports online have described a poorly understood phenomenon following use in naturalistic settings which has been termed reactivation, and refers to the re-experiencing (“flashback”) of some of the effects induced by 5-MeO-DMT intake after the drug’s acute effects have worn off. To date, no research has investigated whether different routes of administration may confer different reactivation rates, effects and experiences.

We aimed to assess whether the occurrence of the phenomenon of reactivation was associated with a specific route of drug administration (i.e. vaporization or intramuscular injection). Secondly, we examined other similarities and/or differences between the two routes of administration with regard to (re)dosing, time of onset, release of physical tension, , as well as satisfaction with life and ratings of the psychedelic experience.

Using internet-based advertisements, 27 respondents completed an online-based survey.

Findings suggest that the intramuscular route of 5-MeO-DMT may produce lower frequency of reactivations, as well as (re)dosing, and evoke higher frequency of somatic release, and has a longer onset of acute effects compared to vaporization. This could be favorable in a clinical trial.