I argue that a posthuman phenomenology focusing on embodied experience is key to understanding psychedelic experiences and their therapeutic value. To do so, it uses this approach to analyze two modes of experience: depression and the psychedelic experiences being used to treat it. This approach differs from neuroscientific and psychological interpretations of ‘experience’ which believe it happens somewhere ‘in’ our heads (either the brain or the mind), thereby reductively betraying the much discussed relevance of ‘set and setting’ on psychedelic experiences. By contrast, a posthuman phenomenology insists that all experience is relational and cannot be separated from its context – thus, challenging the deeply entrenched cartesian dualism in our thinking about subjectivity through an emphasis on embodied subjectivity. Hence, we may ask, where is the ‘mental’ health disorder, in the individual and their brain, or in our embodied relations with the world? By analyzing the two aforementioned modes of experience through the conceptual resources of philosophical and psychiatric phenomenology (with concepts such as incorporation, incorporeality and corporealization), it becomes possible to 1) constructively critique the set up and assumptions of current psychedelic therapy and 2) investigate the structures of experience rather than merely inventorizing ‘subjective effects’, as does much qualitative work under the rubric of ‘phenomenology’. What is at stake is not only applying the conjunction of phenomenology and posthumanism to mental health and psychedelics, but the reverse: to suggest that what we learn from psychiatric research with psychedelics can transcend the therapeutic context and be transformative at a greater level.