Jordan Sloshower

Jordan Sloshower, MD

Yale University

Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic platform


Psychedelic-assisted therapy is based on the premise that psychedelic substances can act as catalysts or adjuncts to psychotherapeutic processes. Recent clinical trials involving psychedelic-assisted therapy have generally employed a similar three-part structure consisting of preparation, support during the dosing sessions, and subsequent “integration.” However, the content of these sessions and the frame through which the therapists approach participants and understand the clinical process has, thus far, been inconsistent among studies. In designing a manualized therapy protocol for a small clinical trial of psilocybin-assisted therapy for major depressive disorder, our group sought to delineate an explicit and replicable, evidence-based model that intentionally builds upon both the neurobiological actions of the medication and the phenomenology of the drug experience. Having identified considerable concordance in proposed mechanisms of change between Acceptance and Commitment Therapy (ACT) and psilocybin therapy, we employed ACT as an overarching psychotherapeutic framework. We hypothesize that the psilocybin experience can provide direct experiential contact with ACT processes that increase psychological flexibility, and that these deeply felt experiences may in turn be reinforced during ACT-informed follow-up therapy sessions. In this presentation, we describe the rationale for selecting ACT, areas of potential synergism between ACT and psilocybin-therapy, the basic structure of our treatment model, and limitations to this approach.


Jordan Sloshower, MD, MSc is a psychiatrist and researcher in the Department of Psychiatry at Yale University. His research and clinical interests focus on therapeutic applications of psychedelic substances and in particular, how psychedelics can be combined optimally with psychotherapy and other healing modalities to treat a variety of conditions. Jordan is a co-founder of the Yale Psychedelic Science Group and is currently an investigator and therapist in two clinical trials of psilocybin-assisted therapy in the treatment of major depressive disorder. This research investigates potential neurobiological and psychological mechanisms of action, namely induction of neuroplasticity and psychological flexibility. He is also a clinical investigator in MAPS’ Expanded Access Program for MDMA-assisted therapy of PTSD. His perspective is informed by prior training in medical anthropology and global health, and deep interests in ethnobotany, Buddhist philosophy, yoga, meditation, and integrative approaches to wellness.



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